Autoimmune Polyglandular Syndromes (APS) - Types 1 & 2: APSs include a wide variety of autoimmune disorders that are divided into a very rare juvenile type 1, and a relatively common adult form type 2. There is also a third type that does not affect the adrenal glands. APS type 1 typically occurs in early childhood, while type 2 most often occurs in one's 30s or 40s. Type 1 is caused by mutations of the autoimmune regulatory (AIRE) gene on chromosome 21. It is inherited in a autosomal recessive manner, meaning both parents must be carriers and pass on the faulty gene in order for their child to be affected. The mutation results in the production of defective proteins which cause the autoimmune destruction of target organs. Type 1 can be diagnosed via genetic testing, but not type 2 since it is caused by complex genetic interactions. Check out this infographic to learn more about autoimmune polyglandular syndromes types 1 & 2:
healtheo360 Wellness Blog
More than 16,000 new cases of lupus are reported every year across the country. Most people develop lupus between the ages of 15-44. Help is needed during the month of May to spread awareness, educate others, and solve the mystery of Lupus.
What is Lupus?
Francois Durand/Getty Images(NEW YORK) -- The rare disease that killed comedy legend Harold Ramis narrows the blood vessels, slowly starving the organs they supply.